摘要
目的 :深入研究心率变异性 (HRV)在高血压病患者中的改变及其与血浆肾上腺素浓度水平变化的关系 ,对高血压病的发病机理与预后影响因素提供新的实验依据 ,期望对临床治疗、各种并发症的预防有新的认识。方法 :对 4 2例健康者、 6 1例轻中度高血压患者进行 2 4h及 5minHRV及血浆肾上素浓度检测。结果 :与对照组比 ,高血压组 2 4hHRV时域分析各指标均下降 (P <0 0 5 ) ,频域指标中极低频功率 (VLF)、低频功率 (LF)显著增高 (P <0 0 1) ;5min短程HRV时域分析SDNN、SDANN下降 (P <0 0 5 ) ,频域分析VLF、LF明显增高 (P <0 0 1) ,LF/HF比值增高 (P <0 0 5 )。与对照组比 ,高血压组血浆肾上腺素浓度显著升高 (P <0 0 1)。结论 :轻中度高血压组患者的交感神经张力亢进的损害比迷走神经张力减弱的损害明显 ,可能是导致高血压靶器官损害的主要原因之一 ;HRV显著降低 ,预示心血管疾病事件发生率、死亡率增加 ,尤其猝死率增加。
Objective: To investigate the autonomic nervous function in essential hypertensive patients by studying heart rate variability(HRV) and plasma adrenalin level Methods: HRV and plasma adrenalin level were evaluate in 42 normal controls,61 essential hypertensive patients group Results: All 24 hours HRV time domain measurements were lower in hypertensive patients groups than those in normal controls( P <0 05) Compared with controls,VLF,LF differed significantly higher in hypertensive patients group in 24 hours HRV frequency domain measurements( P <0 01) Levels of plasma adrenalin of hypertensive patients group was significantly higher( P <0 01)than control groups Conclusion: There are cardiac sympathetic overactivity effects in mild to moderate essential hypertensive patients
出处
《广州医药》
2002年第4期23-25,共3页
Guangzhou Medical Journal
