摘要
目的 探讨超声造影剂对兔肾VX2 肿瘤血流显像的影响。方法 采用超声引导下经皮组织块推注法建立 2 2只兔肾VX2 肿瘤模型 ,经兔耳缘静脉注射利声显 2 0 0mg/ml,应用二次谐波技术和视频密度定量技术观测肿瘤与肾皮质灰阶、能量及频谱在造影前后的变化。结果 造影后肿瘤与肾皮质的灰阶差值由 (1.0 4± 12 .49)dB/cm2 增加到 (11.77±15 .17)dB/cm2 ,能量面积比 (BFAR)差值由 (12 .84± 4.61) %增加到 (2 5 .73± 7.12 ) % ,测得的瘤内血流速度由 (2 2 .0 1±8.16)cm/s增加到 (2 9.5 0± 8.73 )cm/s,多普勒频谱视频密度由 (117.89± 49.74)dB/cm2 增加到 (14 2 .43± 5 1.3 1)dB/cm2 ,P值均小于 0 .0 1。结论 超声造影能显著提高兔肾VX2 肿瘤图像的显示效果 。
Purpose To explore the effect of contrast enhancement on ultrasonography image of rabbit renal VX 2 tumor. Methods There were twenty two rabbit models in which left kidneys were implanted VX 2 tumor. Levovist microbubbles were injected through ear vein at the dose of 200mg/ml. The second harmonic imaging and video density quantitative determination were applied during the observation on the changes of tumor and renal cortex before and after Contrast enhancement. Results Before and after Contrast enhancement, the gray scale balance between kidney cortex and tumor rised from (1.04±12.49)dB/cm 2 to (11.77± 15.17 )dB/cm 2, the BFAR from (12.84±4.61)% to (25.73±7.12)%, the velocity observed of intra tumor blood flow from (22.01±8.16)cm/s to (29.50±8.73)cm/s, the video density quantitative determination of Doppler spectrum from (117.89±49.74)dB/cm 2 to (142.43±51.31)dB/cm 2. Conclusion Contrast enhancement can enhance manifest effect of rabbit renal VX 2 tumor significantly, increase the intensity of Doppler flow signal.
出处
《中国医学影像技术》
CSCD
2002年第7期613-615,共3页
Chinese Journal of Medical Imaging Technology
基金
陕西省科学基金资助 (2 0 0 1SM 47)
