摘要
目的 论述异种移植排斥反应的发生机制和各种免疫细胞的相互作用。方法 结合基础研究相关资料对异种移植免疫学研究成果和新进展作一回顾。结果 转基因猪技术 ,新型免疫抑制剂等分别用以克服超急性排斥 ,急性血管性排斥 ;急性细胞性排斥的克服采用了针对 T细胞、抗原递呈细胞的策略以及诱导免疫耐受等方法。结论 转基因猪技术较为成熟而有效 ;急性血管性排斥 ,急性细胞性排斥的发生机制和克服仍有待进一步研究。
Objective To investigate the mechanism of xenotransplantation rejection and the interaction between the immunocytes. Methods This review concluded the research achievements and new advances in xeno transplantation based on the relevant experimental data. Results Transgenic pig technology and novel immunosuppressants were applied to suppress hyperacute rejection and acute vascular rejection respectively. Modulation of T cell and antigen presenting cells and induction of tolerance were taken for the prevention of acute cellular rejection. Conclusion In general, the technology of transgenic pig is relatively mature and effective. The mechanism and prevention of acute vascular rejection and acute cellular rejection should be further investigated.
出处
《中国修复重建外科杂志》
CAS
CSCD
2002年第4期284-287,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目 (39993430 )
关键词
异种移植
移植免疫
排斥反应
Xenotransplantation Transplantation immunology Rejection
