摘要
目的 :研究TNF -α、GM -CSF及HA三项标记物与哮喘病情变化的关系。方法 :三项标记物均采用放射免疫分析法。研究对象包括 6 6名患者及 3 0名对照组。结果 :哮喘发作组 (n =3 6 )血清TNF -α、GM -CSF及HA水平均显著高于正常对照组 (p <0 0 1 ,p <0 0 1 ,p <0 0 5 )。而哮喘缓解组 (n =3 0 )则三项标记物均显著下降 ,但与正常对照组比较差异仍有显著性 (p <0 0 5 )。结论 :三项标记物的变化与哮喘的发作关系密切 。
Objective To study the relationship between the diversity of the state of asthma and the three serum markers (TNF-α, GM-CSF and HA). Methods RIA was adopted to measure the three markers in 66 asthmatic patients and 30 controls. Results The levels of the three markers in patients during attack (n=36) were significantly higher than those in controls ( p<0 01,p<0 01,p<0 05 ). The three markers declined significantly in remission group (n=30), but were still signifcantly higher than those in controls ( p <0 05). Conclusion There is a close relationship between the levels of the three markers and the attack of asthma. Immunomodulator is therefore suggested to be used in addition to antiinflammatory treatment.
出处
《放射免疫学杂志》
CAS
2002年第3期133-134,共2页
Journal of Radioimmanology
