摘要
以苯胺类化合物为起始原料 ,经重氮化、丙烯酸加成、氨解等过程合成了 5种消旋苯环取代苯丙氨酸衍生物 ,并采用α-糜蛋白酶和枯草杆菌蛋白酶对所有氨基酸进行了拆分 ,通过 IR,1 H NMR,元素分析和旋光等技术进行表征 .其中
Five kinds of racemic ring modified phenylalanines were synthesized by using aniline derivatives as the raw materials and further characterized with routine analysis. Most of the amino acids were resolved with chymotrypsin or subtilisin and some protected forms of the amino acids were obtained. The possible mechanism of the method for the relatively large scale synthesis was discussed. These unusual amino acids were used as the building blocks for peptide based antagonists. It had latent investigation values that the physicochemical properties and metabolism behavior in vivo of the peptide containing the amino acids were changed.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2002年第7期1314-1317,共4页
Chemical Journal of Chinese Universities
基金
军事医学科学院创新基金资助
