摘要
为初步探讨发生SLE脑损害(NPLE)的危险因素,对17例NPLE患者及29例无脑损害的SLE(非NPLE)患者进行临床表现及实验室检查结果方面的统计学比较,并分析NPLE与各临床特点之间的相关性。结果显示,NPLE病组发热、血小板减少、抗Sm抗体阳性、脑脊液(CSF)抗核抗体(ANA)阳性、CSF蛋白增加及氯化物减少的发生率显著高于非NPLE组(P<0.05),而盘状红斑发生率则显著低于非NPLE组(P<0.05);发热、血小板减少、抗Sm抗体阳性、CSFANA阳性、CSF蛋白增加及氯化物减少可能是发生NPLE的危险因素,盘状红斑及抗Ro抗体阳性可能是NPLE的保护性因素。
We investigated risk factors, in clinical situations and laboratory examinations, for CNS involvement in SLE in 17 patients (NPLE) compared with 29 control SLE patients without CNS involvement (non NPLE), and analyzed the correlation between NPLE and clinical manifestation. The results showed that in NPLE there are significant increases of fever, thrombocytopenia, positive anti-Sm antibodies, positive antinuclear antibodies(ANA) in cerebrospinal fluid(CSF), the higher proteins and lower chloride in CSF, while significant decrease in discoid rash. Fever, thrombocytopenia, positive anti Sm antibodies, positive ANA in CSF, the high proteins and low chloride in CSF may be risk factors for NPLE, while discoid rash and anti Ro antibodies may be protective factors for NPLE.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2002年第7期426-428,共3页
Journal of Clinical Dermatology
关键词
系统性红斑狼疮
脑脊液
危险因素
脑损害
临床表现
lupus erythematosus,systemic
central nervous system
cerebrospinal fluid
risk factors
