摘要
为研究白藜芦醇在体内的雌激素样作用 ,给刚断乳小鼠分别皮下注射和灌胃不同剂量的白藜芦醇 ,观察该物质对子宫和阴道的影响。结果显示 ,2 0mg kg .BW的白藜芦醇可明显促进未成熟小鼠阴道开口 (P <0 0 5 )和阴道上皮角化 ,显著增加子宫重量及其系数 (P <0 0 5 ,P <0 0 1) ,并可使子宫内膜柱状上皮增厚或腺体增生。结果表明白藜芦醇在体内具有雌激素样作用。
To investigate the estrogenicity of trans resveratrol in vivo, different doses of trans resveratrol were administered orally (ig.) or subcutaneously (sc.) to the weanling mice for 4 d. The results showed that 2 0 mg/kg.b.w of trans transveratrol (ig or sc) could shorten vaginal opening latency periods ( P <0 05) and enhance keratinization of vaginal epithelium dramatically, increase uterine wet weights and uterine body weight ratios significantly ( P <0 05, P <0 01). Additionally, trans transveratrol could thicken the columnar epithelial cells or increase the numbers of glands in uterine in immature mice. It was concluded that trans transveratrol could appear estrogenic actions in vivo. Moreover, its activity via subcutaneous administration was higher than that via oral administration.
出处
《卫生研究》
CAS
CSCD
北大核心
2002年第3期188-190,共3页
Journal of Hygiene Research
