摘要
目的 探讨先天性唇腭裂（cleft lip and palate,CLP）的发病危险因素。方法 对189例 CLP患儿的母亲及60例非CLP患儿的母亲进行成组病例对照研究,调查内容包括可能引起CLP发生的危险因素,用非条件Lo-gistic回归方法进行单因素和多因素分析。结果 单因素分析显示与唇裂伴或不伴腭裂（CL ± P）发病有显著性意义的因素共8种,最终进入多因素Logistic回归模型的变量有家族史、O型血、出生季节（5月～7月）和母亲职业:与腭裂（CP）发病有显著性意义的因素共4种,进入多因素 Logistic回归模型的变量为胎次、出生季节（11月～次年1月）和母亲职业。结论 环境和遗传因素是CL±P的主要发病因素,而CP则主要与环境因素有关。
ve To study the risk factors in the occurrence of cleft lip and palate (CLP). Methods 189 CLP mothers and 60 normal mothers were studied in a case-control study. The investigation included the risk factors which may cause CLP. Nonconditional stepwise logistic model to simple factor and multivariate analysis was used. Results According to simple factor analysis, 8 factors were significantly related with cleft lip with or without palate (CL ± P)and 4 factors related with cleft palate (CP) . In the multiple logistic regression model, only family history, blood type(O), birth season (May -July ) and mother occupation were related with CL ± P and only number of pregnance, birth season (November - January) and occupation related with CP, Conclusion Hereditary and environmental factors may be the risk factors for occurrence of CL ± P, but only environmental factor is the risk factor for occurrence of CP.
出处
《口腔颌面外科杂志》
CAS
2002年第2期104-106,共3页
Journal of Oral and Maxillofacial Surgery
