摘要
目的:通过对影响唇腭裂的可疑因素分析,旨在探讨其发病危险因素。方法:对我院2003年CLP及同期省人民医院的非CLP患儿和母亲进行病例对照研究,用非条件logistic回归分析来评价指标。结果:在10项指标中,唇裂伴或不伴腭裂(CL±P)单因素分析中有4项指标具有显著意义(P<0.05),腭裂(CP)发病有5项指标具有显著意义(P<0.05),分别进入Logistic逐步回归方程,结果表明家族史、母亲职业是CL±P发病的危险因素;患儿体重、母亲职业是CP发病的危险因素。结论:遗传因素在CL±P的发病中具有显著意义,怀孕期间患病、用药可导致唇腭裂发病的相对危险度增加。
Objective： The purpose of this study is to evaluate the risk factors of cleft lip and palate （CLP）. Methods： 508 CLP mothers and infants accompanied with 134 normal control pairs were studied. A logistic regression model to simple factor and multivariate analysis was used. Results： According to simple factor analysis, 4 factors were significant with cleft lip with or without palate（ CL±P） ;5 factors were significant with cleft palate （CP）. In the multiple logistic regression model, the family history and mother occupation were involved in CL±P, the infants height and mother occupation were involved in CP. Conclusion： The hereditary factor plays a significant role in CL±P. The relative risk of CLP could increase when mothers suffer from disease and take drugs in the period of pregnancy.
出处
《口腔医学研究》
CAS
CSCD
2005年第4期449-451,共3页
Journal of Oral Science Research
