摘要
目的 :探讨任意尿香草扁桃酸 /肌肝 (VMA/ Cr)和高香草酸 /肌肝 (HVA/ Cr)测定对神经母细胞瘤的诊断价值。方法 :5 0例 1～ 5岁正常儿童和 11例 2～ 5岁神经母细胞瘤患儿的任意尿标本 ,用高效液相色谱法测定VMA、HVA浓度 ,Beckmann自动生化分析仪测定肌酐 (Cr)浓度 ,计算 VMA/ Cr、HVA/ Cr。结果 :1～ 5岁儿童的99%正常值范围为 VMA/ Cr<14 .9mmol/ mol,HVA/ Cr<2 3.8mmol/ mol。 11例神经母细胞瘤患儿中有 10例VMA/ Cr和 HVA/ Cr均超过正常值范围 ,诊断符合率 90 .9%。结论 :任意尿 VMA/ Cr和 HVA/ Cr测定采样方便 ,诊断符合率高 ,可取代 2 4 h尿 VMA、HVA总量测定法用于神经母细胞瘤术前诊断和术后随访。
Objective: To evaluate the VMA/Cr and HVA/Cr of random urine in the diagnosis of neuroblasto ma. Methods: VMA/Cr and HVA/Cr were examined in 50 normal children and 11 cases of neuroblastoma (NB) aged 1～5 years.The concentration of 4 hydroxy 3 methoxy mandelic acid (VMA) and homovanillic acid (HVA) in random urine collection were analyzed by high performance liquid chromatography and creatinine (Cr) analyzed by auto biochemical analyzer. Results: The normal range of VMA/Cr and HVA/Cr were<14.9 mmol/mol and <23.8 mmol/mol, respectively.The positive rate of VMA/Cr and HVA/Cr in NB patients was 90.9%. Conclusion: Determination of VMA/Cr and HVA/Cr in random urine collection can be used for NB diagnosis.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2002年第3期219-221,共3页
Journal of Zhejiang University(Medical Sciences)
关键词
香草扁桃酸
高香草酸
肌酐比值
诊断
神经母细胞瘤
尿
Neuroblastoma/diag
Vanillylmandelic acid/urine
Homovanillic acid/urine
Creatinine/urine
