摘要
目的:探讨益妇止血丸的药理作用。方法:以家兔为观察对象,灌胃给药检测各组家兔血中部分凝血活酶时间(PPT)、复钙时间(RT)、凝血酶原时间(PT)、血小板计数和血小板粘附率。体外给药检测各组家兔血中部分凝血活酶时间(PPF)、复钙时间(RT)、凝血酶原时间(PT)。用离体子宫实验检测对已服用和未服用雌激素的家兔离体子宫的收缩节律与强度作用。结果:益妇止血丸能促进家兔内源性凝血功能,使PPT和RT时间显著缩短,其促凝作用的机理与安络血相似,但与血小板的粘附聚集和外源性的促凝系统无关。对服用和未服用己烯雌酚的兔离体子宫平滑肌具有同样的兴奋作用,加强其收缩的幅度和频率。
Objective:To investigate the pharmacological effect of Yifuzhixue Pill (YFZXP). Methods: PPT,RT,PT, platelet counts and platelet adhesive rate were examined after administration of YFZXP. In other hand, the functions of isolated rabbit's uteri were also examined to determine whether they were responsible to the administration of YFZXP. Results: YFZXP could enhance the intrinsic blood coagulating function and stimulate the contraction of smooth muscles of uterus including increasing the rhythms and strength.The stimulation effect of YFZXP on smooth muscles of uterus exhibited no selections between the uteri treated with or without estradiol. It was speculated that the increased intrinsic blood coagulating and uterus' contraction induced by YFZXP were contributed to its anti-bleeding effect in uterus.
出处
《中药材》
CAS
CSCD
北大核心
2002年第6期418-420,共3页
Journal of Chinese Medicinal Materials
