摘要
Yatvin成功地用温度敏感脂质体进一步提高了脂质体在靶治疗中的中靶功能。本文还根据荷瘤肝脏的血流分布特性,将研制成功的阿霉素(adriamycin)温度敏感脂质体注入肝动脉,并与热疗相结合,对阿霉素温度敏感脂质体的体内行为和疗效进行研究,证明有提高抗肝癌疗效的可能。
Temperature sensitive liposome entrapped adriamycin was injected into the hepatic artery of Wistar rats bearing implanted hepatic tumor. Two hours after the injection, the liver was heated to 42 ℃ and maintained at that temperature for 6 minutes using a local hyperthermia. The variation in the pattern of the concentration of the liposomal drug in circulation, and the drug distribution in tissues were investigated. Results indicated that adriamycin was released from the liposomes with the drug concentration peaking in circulation at 30 minutes after heating. Following the hyperthermia treatment, the total amount of drug in the liver decreased, while that in the tumor and urine increased. The ^(14)C labeled liposome track test showed that a parallel relationship between the lipid and the drug was maintained for 8 hours after the hepatic injection, and physiological environment was a determinant of change and existence of liposomal carrier. However, the drug encapsulated in the liposomes can be controlled by hyperthermia to target the tumor.Therapeutic experiments showed that in the group treated with the hepatic artery- injected liposome plus hyperthermia control, the liver tumor growth of the rats administered at 7 days after W_(256) carcinosarcoma implantation on liver was notably inhibited and the life-span of the animal was greatly extended compared with those of aqueous administration groups and ⅳ injected liposome group.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第9期705-709,共5页
Acta Pharmaceutica Sinica
关键词
温度敏感
脂质体
阿霉素
靶行为
Tempera ture sensitive liposome
Adriamycin
Liposome
Targeted bdhavior
