摘要
呋喃二氢吡啶Ⅰ20μmol╱L能使离体兔心局部缺血心肌肌酸磷酸激酶(CPK)和α-羟丁酸脱氢酶(HBD)的释放量明显减少;冠脉阻力下降,流量增加;并能降低血浆及心肌中钙、钠含量,预防缺血性心律失常的发生。提示该药对离体兔心缺血心肌的保护作用,与降低缺血心肌细胞钙、钠含量有关。
A recirculating nonpulsatile perfusion circuit was used in isolated rabbit hearts. Furyl-dihydropyridine Ⅰ( 2, 6 - dimethyl - 4 - furyl - 1, 4 - dihydropyridine-3, 5-dicarboxylate)20μmol/L was shown to inhibit the release of creatine phosphokinase (CPK) and α-hydroxybutyrate dehydrogenase (HBD) from myocardium, decrease myocardial calcium and sodium contents by 5.3±1.1μmol/g dry weitght (P<0.01, n=6) and 1.50±0.17mmol/g dry weight (P<0.05, n=6) from 8.3±1.1μmol/g dry weight and 1.96±0.32 mmol/g dry weight respectively. It was alse found to reduce coronary resistance and increase coronary flow of the ischemic myocardium, and prevent ischemic arrhythmia, thereby limit myocardial injury during regional ischemia in isolated rabbit hearts.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第2期86-90,共5页
Acta Pharmaceutica Sinica
关键词
呋喃二氢吡啶
心肌缺血
保护作用
Furyl-dihydropyridine I
Ischemic myocardium
Arrhythmia
Creatine phosphokinase (CPK)
α-Hydroxybutyrate dehydrogenase (HBD.).
