摘要
在实验室模拟移动床（SMB）分离设备上成功地实现了木糖醇母液中木糖和木糖醇组份的分离提纯，并在平衡理论的框架下，采用基于真实移动床（TMB）的简化数学模型，以产品纯度和收率为系统分离性能的优化指标，研究SMB分离性能与操作条件之间的关系。通过对木糖醇母液SMB色谱分离过程操作条件的寻优仿真研究，确定稳态时柱内的木糖和木糖醇浓度分布状态；计算出不同操作条件时两组分产品液各自的纯度和收率变化规律图。在阀门切换时间为15min，进料木糖醇母液中木糖浓度35g·L^-1,木糖醇浓度114g·L^-1,进料和出料总量恒定为16mL·min^-1,循环洗脱剂流量恒定为18mL·min^-1的操作条件下，木糖醇母液进料流量在1－2．3mL·min^-1范围内都可同时获得纯净木糖醇与木糖产品。在实验室SMB分离设备上进行了验证，得到的木糖和木糖醇产品液纯度和收率均达到了100％，所有实验结果与仿真曲线基本吻合。因此采用基于TMB的简化的平衡理论模型进行仿真和优化研究可分析和预测木糖母液SMB色谱分离系统操作条件对系统分离性能的影响，有效地指导了产品分离实验、工业化放大设计和生产优化操作。
On a laboratory simulated moving bed (SMB) system, the xylitol mother liquor was successfully separated and purified into xylose and xylitol component. In the frame of equilibrium theory, taking purity and recovery as performance index, the relationship between the operation condition and the SMB performance was studied, by using a simplified mathematical model of the corresponding true moving bed (TMB). Then the simulation by computer and optimization of SMB chromatographic separate condition for xylose mother liquor also was studied. Through confirming the concentration distribution-estate of xylose and xylitol in the column on the steady state, the change rule of purities and recoveries of two product liquors was obtained. The satisfaction result was gotten on a SMB equipment in our labor, the purities and recoveries of xylose and xylitol product liquor all reached 100% under the optimized operation conditions: switching time of valve 15 min; xylose 35gL-1 and xylitol 114gL-1 in the xylose mother liquor; flow-in and -out rates of SMB system 16mLmin-1; recycle flow rate of elution 18mL穖in-1; feed rate range of xylose mother liquor between 1.0 and 2.3mlmin-1. So, it can be validated that the equilibrium theory model can be used to analyses and dope out the influence of separate performance from various operation conditions in the SMB chromatographic system for xylose and xylitol separation. The modee can also be used to direct the separation experiment and to optimize the scale-up design or the industrial production of chromatographic separation process.
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
2002年第3期270-274,共5页
Journal of Chemical Engineering of Chinese Universities
基金
教育部高校骨干教师资助基金
教科司(2000-65)。
关键词
分离性能
优化
模拟移动床
木糖醇母液
色谱
木糖
氢化
甜味剂
simulated moving bed
xylitol mother liquor
chromatographic separation
optimization of operate-condition
