摘要
8310是一种新型M_2受体激动剂,icv 0.5、1、2、4μg/kg呼吸频率、潮气量、每分通气量均明显减少,并呈量效依赖关系,PaO_2明显降低,PaCO_2明显增加;iv 10μg/kg亦致明显呼吸抑制。结果提示8310对呼吸中枢产生抑制,可能与激动呼吸中枢抑制型M_2受体有关。
In the conscious rabbit, the respiratory frequency ( FR ) , tidal volume ( Vt ) , minute ventilation ( Vm ) and the Pa02, PaC02 and PH of the arterial blood were determined. The administration of a novel selective M2 receptor agonist, 8310 0.5-4.0μg/kg icv or 10ng/kg iv, caused decrease in FR, Vt, Vm and PaO2 and increase of PaCO2, and its dose-effect relationship in Vm was linear ( r = 0.998, P<0.01 ) . Our results suggest that the central inhibitory action of 8310 on respiration might be related to the stimulation of the inhibitory M2 cholinergic receptor in respiratory center.
出处
《徐州医学院学报》
CAS
1991年第1期12-15,共4页
Acta Academiae Medicinae Xuzhou
关键词
受体激动剂
8310
呼吸
M2 cholinergic receptor, agonist of
8310
respiration
determination of arterial blood gases
rabbits
