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整合蛋白连接激酶:抗肿瘤药物作用的新靶点 被引量：3

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摘要 整合蛋白连接激酶 (integrin linkedkinase ,ILK)是一个Ser/Thr蛋白激酶。它能介导细胞与胞外基质的相互作用 ,并通过下游底物蛋白激酶B和糖原合成酶激酶 3将胞外信号向下游传递。从而增强细胞的侵袭能力、促进细胞周期循环的进行并抑制细胞凋亡。一些蛋白磷酸酶如PTEN和ILKAP能够对ILK的活性或其信号传导途径进行抑制 ,一些小分子的ILK拮抗剂也能抑制ILK的活性。抑制ILK可使细胞恶性度和成瘤能力下降 ,导致细胞凋亡和G1到S期细胞周期循环的停滞。这些结果显示 ,抑制ILK的活性将对某些肿瘤的治疗有着非常重要的意义。近来一些研究显示 ,某些非甾体类抗炎药。
作者 林梁 黄常志
机构地区 中国医学科学院/中国协和医科大学肿瘤研究所
出处 《国外医学（药学分册）》 2002年第3期134-138,共5页 Foreign Medical Sciences(Section of Pharmarcy)
基金 国家自然科学基金资助项目 (3 0 1710 89
关键词 整合蛋白连接激酶 抗肿瘤药物作用 蛋白激酶B 糖原合成酶激酶3 蛋白激酶 蛋白磷酸酶
分类号 R73-36 [医药卫生—肿瘤]
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参考文献22

  • 1Radeva G, Petrocelli T, Behrend E, et al. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression[J]. J Biol Chem, 1997, 272(21): 13937 - 13944.
  • 2Hunnigan GE, Lerng-Hagesteijn C, Fitz-Gibbon L, et al.Regulation of cell adhesion and anchorage-dependent growth by a new β1 integrin-linked protein kinase [J]. Nature,1996, 379(6560):91 - 96.
  • 3Dedhar S, Williams B, Hannigan G. Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signaling [J]. Trends Cell Biol, 1999, 9(8):319 - 323.
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同被引文献12

  • 1Marotta A,Parhar K,Owen D,et al.Characterisation of integrin-linked kinase signalling in sporadic human colon cancer[J].Br J Cancer,2003,88(11):1 755～1 762.
  • 2Ito R,Oue N,Zhu X.Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma[J].Virchows Archiv,2003 442 (2):118～123.
  • 3Dedhar S,Willia B,Hannigan G.Integrin-linked kinase(ILK):a regulator of integrin and growth-factor signaling[J].Trends Cell Biol,1999,9(8):319～323.
  • 4Grashoff C,Thievessen I,Lorenz K,et al.Integrinlinked kinase:integrin' s mysterious partner [J].Curr Opin Cell Biol,2004,16(5):565-571.
  • 5Cho HJ,Youn SW,Cheon SI,et al.Regulation of Endothelial Cell and Endothelial Progenitor Cell Survival and Vasculogenesis by Integrin-Linked Kinase [J].Arterioscler Thromb Vasc Biol,2005,25(6):1 154-1 160.
  • 6Tan C,Cruet-Hennequart S,Troussard A,et al.Regulation of tumor angiogenesis by integrin-linked kinase (ILK) [J].Cancer Cell,2004,5 (1):79-90.
  • 7Persad S,Attwell S,Gray V,et al.Inhibition of integrinlinked kinase (ILK) suppresses activation of proteinkinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(7):3 207-3 212.
  • 8Graff JR,Deddens JA,Konicek BW,et al.Integrinlinked kinase expression increases with prostate tumor grade [J].Clin Cancer Res,2001,7(7):1 987-1 991.
  • 9Tan C,Costello P,Sanghera J,et al.Inhibition of integrin linked kinase (ILK) suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the Ecadherin repressor,snail,in APC-/-human colon carcinoma cells[J].Oncogene,2001,20(1):133～140.
  • 10方全.整合素与血管生成[J].国外医学（免疫学分册）,2002,25(1):17-20. 被引量：5

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国外医学（药学分册）
2002年 第3期

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