摘要
目的 :了解头孢哌酮对茶碱药代动学的影响 ,为临床合理使用茶碱提供数据。方法 :采用高效液相色谱法测定家兔体内茶碱浓度 ,用T形法求算药动学参数。结果 :头孢哌酮使茶碱的AUC ,T1/ 2 和Vd下降 ;Ke升高 ;CL 无明显变化。结论 :头孢哌酮对茶碱药代动力学参数有影响 。
Objective: Probe the effect of Cefoperazone on the pharmacokinetics of Theophylline so as to provide the data for using Theophylline rationally in clinic. Methods:Six rabbits were administrated Theophylline by venous injection at the dose of 10mg/kg. Blood samples taken from ear venous at different time were detected by HPLC.Draw the drug -time curve of Theophylline.After a week of taking Cefoperazone at the dose of 40mg/kg i.m per day ,draw the drug-time curve again.Take the T shape method to calculate the pharmacokinetics parameters.Results: Cefoperazone changed the parameter of Theophylline as follows: AUC, T 1/2 and Vd decreased; Ke increased while C L had no changed.Conclusion:Cefoperazone had some effects on the parameter of Theophylline.The dose of Theophylline should be modulated when combined with Cefoperazone in clinical treatment.
出处
《牡丹江医学院学报》
2002年第3期1-2,共2页
Journal of Mudanjiang Medical University
