摘要
目的观察盐酸哌唑嗪对单剂量给药的地高辛血药浓度或多次给药的地高辛稳态血药浓度的影响 ,为临床合理用药提供实验依据。方法给家兔灌胃地高辛20μg/kg,盐酸哌唑嗪150μg/kg,于家兔耳缘静脉定时采血 ,应用荧光偏振免疫法测定地高辛血药浓度 ,比较应用盐酸哌唑嗪前后地高辛血药浓度。结果单次给地高辛时 ,盐酸哌唑嗪可延长地高辛的吸收和消除过程 ;多次服用地高辛时 ,在合用盐酸哌唑嗪6h后 ,地高辛的稳态血药浓度显著提高。结论临床合用地高辛和盐酸哌唑嗪时应严格个体化给药 。
Aim To study the influence of prazosin hydrochloride on plasma digoxin levels when prazosin hydrochloride was added after administration of single dose or multiple doses of digoxin. Methods After po 20μg/kg of digoxin with or without addition 150μg/kg of prazosin hydrochoride, the rabbit plasma digoxin levels were monitored by TDX. T-test was used to evaluate the difference between the plasma digoxin levels after prazosin hydrochloride was added or not. Results The absorption course and elimination course of digoxin were prolonged when single dose of digoxin was given, and after multiple doses of digoxin, the steady state concentrations of digoxin were significantly raised when single dose of prazosin hydrochloride was given 6h later. Conclusion The plasma digoxin levels should be adjusted individually for the patients who use digoxin combined with prazosin chronically.
