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B7家族-重要的共刺激分子 被引量：11

B7 family-important co-stimulatory molecules
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摘要 B7家族属免疫球蛋白类 ,目前已发现 5种 ,即B7 1,B7 2 ,B7 H1,B7 H2和B7 H3等。它们结构相似 ,均可在机体免疫过程中作为共刺激因子 (第 2信号 ) ,与T、B细胞的活化和机体免疫有关。B7家族在肿瘤治疗、器官移植和自体免疫病的治疗方面有重要作用 ,在基础研究方面则可以用于T、B细胞分化、活化机制、抗原提呈、共刺激机制、免疫耐受。 B7 family is a group of co stimulators ( second signals) and correlates with T, B cell activation and immunologic functions, belongs to immunoglobulin (Ig) superfamily and consists of B7 1, B7 2, B7 H1, B7 H2 and B7 H3. B7 family has an important implications in the treatment on cancers, trans and auto immune diseases. In fundamental study, it can be used in study on T, B cell differentiation and activation, antigen presentation, co stimulating mechanism, immune tolerance, transplant rejection and auto immune.
作者 雷呈祥
机构地区 复旦大学生命科学学院遗传工程国家重点实验室
出处 《免疫学杂志》 CAS CSCD 北大核心 2002年第B06期54-57,共4页 Immunological Journal
关键词 B7 共刺激 T细胞活化 免疫耐受 移植排斥反应 自体免疫 B7 co stimulation T cell activation immune tolerance
分类号 R392.11 [医药卫生—免疫学] R392.4 [医药卫生—免疫学]
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二级参考文献18

  • 1Chen L,Ashe A,Brady WA,et al.Costimulation of antitumor immunity by the B7 counter-receptor for the T lymphocyte molecule CD28 and CTLA-4. Cell . 1992
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  • 3Linsley PS,Brady W,Grosmaire L,et al.CTLA-4 is a second receptor for B cell activation antigen B7. The Journal of Experimental Medicine . 1991
  • 4Zheng P,Wu Y,Guo Y,et al.B7-CTLA-4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge. Proceedings of the National Academy of Sciences of the United States of America . 1998
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  • 6Linsley PS,Brady W,Grosmaire L,et al.Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. The Journal of Experimental Medicine . 1991
  • 7Freeman GJ,Freedman AS,Segil JM,et al.B7 a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol . 1989
  • 8Inobe M,Linsley PS,Ledbetter JA,et al.Identification of an alternatively spliced form of the murine homologue of B7. Biochemical and Biophysical Research Communications . 1994
  • 9Guo Y,Wu Y,Kong X,et al.Identification of conserved amino acids in murine B7-1 IgV domain critical for CTLA-4/CD28: B7 interaction by site-directed mutagenesis: a novel structural model of the binding site. Molecular Immunology . 1998
  • 10Milich D,Linsley PS,Hughes JL,et al.Soluble CTLA-4 can suppress autoantibody production and elicit long term responsiveness in a novel transgenic model. J Immunol . 1994

共引文献2

同被引文献71

  • 1张惠丽,奚永志,孔繁华.T细胞激活的信号传导及阻断[J].免疫学杂志,2000,16(z1):5-8. 被引量：4
  • 2李慧,任秀宝,郝希山.B7家族的新成员—B7-H1、B7-H2、B7-H3、B7-DC[J].国外医学（免疫学分册）,2005,28(1):41-43. 被引量：5
  • 3余敏,李大金,王秀丽,袁敏敏,朱影,姚晓英,李华萍.分子佐剂C3d上调Raji细胞协同刺激分子B7-1和B7-2的表达(简报)[J].分子细胞生物学报,2006,39(1):77-82. 被引量：6
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引证文献11

二级引证文献41

免疫学杂志
2002年 第B06期

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