摘要
目的 探讨碘过剩与甲状腺疾病的关系。方法 观察不同浓度的高碘对大鼠甲状腺的影响 ,以及对人类甲状腺滤泡上皮细胞的作用。结果 实验动物组均出现弥漫性胶质性甲状腺肿 ,随着投碘量的增加 ,甲状腺绝对与相对重量与正常对照组比均见明显增加 (P <0 .0 0 5 ) ;不典型增生区域增多 ;甲状腺滤泡上皮高度降低 ,甲状腺滤泡腔面积扩大 ,核仁组成区嗜银蛋白 (AgNOR )计数增加 ,与正常对照组比较均有明显差异 (均P <0 .0 0 1)。培养的人甲状腺滤泡上皮细胞在碘浓度 0 .75 μg/ml中 6 %～ 2 5 %的细胞出现变形 ,线粒体、粗面内织网及绒毛增多 ;碘浓度 3.75 μg/ml时 ,30 %～ 40 %细胞表现为线粒体肿胀 ,粗面内织网扩张 ;碘浓度 18.75 μg/ml时 90 %细胞溶解 ,可见层状小体。 结论 过量摄碘与甲状腺机能亢进症 ,甲状腺机能减退症 ,甲状腺炎及甲状腺癌等疾病的发生可能有密切关系。
Objective To determine the relationship between excess iodine and the thyroid diseases. Methods The effects of excess iodine on rat thyroid and human thyroid cell were observed . Results All the rats in the experimmental group had diffuse colloidal goiter.With the increase of iodine levels,the relative and absolute weight of the goiter increased and revealed atypical abnormal hyperplasia as compared with the control group. The heights of thyroid follicular epithelial cells were decreased and the areas of thyroid follicular spaces were enlarged(p<0.001). Silver stained nuclear organized regions(AgNOR) were increased and significantly greater than those in control group(p<0.001). When the iodine concentration of the cultured human thyroid follicular epithelial cells was 0.75μg/ml, 6% to 25% of the cells showed deformed mitochondria with rough endoplasmic reticulum and increased microvilli. If the iodine concentration was 3.75μg/ml, 30% to 40% of the cells showed mitochondria swelling with rough endoplasmic reticulum dilatation. When iodine concentration was 18.75μg/ml, 90% of the cells dissolved. Conclusions Excess iodine may be closely related to the development of various kinds of thyroid diseases, such as hyperthyroidosm, hypothyroidism , thyroiditis and thyroid cancer.
出处
《中国普通外科杂志》
CAS
CSCD
2002年第5期293-296,共4页
China Journal of General Surgery
