摘要
目的 探讨乙型肝炎病毒不同复制程度对肝纤维化进程的作用。方法 173例患者分为 6组 :慢性肝炎轻、中、重度 3组 ,肝硬化Child -PughA级、B级、C级 3组 ,采用放射免疫法测定慢性乙型肝炎、肝硬化患者血清白细胞介素 - 6 (IL -6 )、白细胞介素 - 8(IL - 8)、Ⅲ型前胶原 (PⅢP)、Ⅳ型胶原 (c -Ⅳ )含量 ,并同时测定HBV -DVA ,按阳性、阴性不同进行分组比较。结果 血清IL - 6、IL - 8、PⅢP、c -Ⅳ含量 ,当HBV -DNA(+)时与HBV -DNA(- )时相比较 ,除在肝炎轻度组、肝硬化C级组无显著差异外 (P >0 0 5 ) ,其余 4组皆有统计学意义 ,以重度组、A级组为显著 (P <0 0 1)。结论 乙型肝炎病毒活跃复制可加重肝脏损害 ,促进肝星状细胞 (HSC)的活化及活化持续 ,从而在肝纤维化的起始。
Objective To study the role of replication of hepatitis B virus in the course of liver fibrosis.Methods 173 patients were divided into six groups:mild,middle and severe chronic hepatitis B(CHB) groups,and Child Pugh(CP) A, B, and C groups;and each group was divided into two subguorps according to HBV DNA.The serum levels of interleukin 6,interleukin 8(IL 8),procollagen Ⅲ peptide (PⅢP), and collagen type IV(c IV) were measured in each patient by radioimmunoassay(RIA).The results were compared between HBV DNA(+) and HBV DNA(-) subgroups.Results Except in mild CHB and CP-C groups (P>0 05),the serum level of IL 6,IL 8 and PⅢP?c Ⅳ were significantly higher in HBV DNA positive subgroup than in HBV DNA negative subgroup (P<0 01),especially in severe CHB and CP A groups (P<0 01).Conclusions The active replication of hepatitis B virus can aggravate the injury of liver,activate the hepatic stellate cells and make the activation couise continue.Hence the active replication of hepatitis B virus plays an important role in the initial stage and the progressive stage of liver fibrosis.
出处
《武警医学》
CAS
2002年第6期329-331,共3页
Medical Journal of the Chinese People's Armed Police Force
