摘要
目的 探讨血清CA12 5测定在卵巢上皮性癌诊断及判断预后中的价值。方法 用放射免疫法测定 82例卵巢上皮性癌术前血清CA12 5水平。结果 以血清CA12 5>35u .ml-1为异常值 ,卵巢上皮性癌检出的阳性率 ( 95 .12 % )与以>2 0 0～ 30 0u .ml-1为异常值的阳性率 ( 92 .6 8%～ 90 .2 4% )无差异 (P >0 .0 5 ) ;在卵巢上皮性癌组织类型中 ,浆液性囊腺癌和未分化癌血清CA12 5水平高于其它类型 (P均 <0 .0 5 ) ;卵巢浆液性囊腺癌临床Ⅲ -Ⅳ期、病理Ⅱ -Ⅲ级血清CA12 5明显高于临床Ⅰ -Ⅱ期和病理Ⅰ级 (P <0 .0 0 5～ <0 .0 2 )。结论 血清CA12 5>2 0 0～ 30 0u .ml-1,卵巢上皮性癌的可能性极大 ;血清CA12 5的测定有助于卵巢上皮性癌组织类型的鉴别及预后的判断。
Objective To study the diagnostic and prognostic value of serum CA 125 on epithelial ovarian carcinoma.Methods By using radioimmuoassay,CA 125 concentration in serum was measured in 82 patitents with epithelial ovarian carcinoma.Results The positive rate (95.12%) of epithelial ovarian carcinoma using serum CA 125 >35u.ml -1 showed no obvious difference from that (92.68～90.24%) of CA 125 >200～300u.ml -1 (P>0.05).The serum CA 125 concentration in ovarian serous cystadenocarcinoma and undifferentiated carcinoma was higher than that in the other histological type (P<0.05).The serum CA 125 concentration in Ⅲ-Ⅳ stage and patholgoical Ⅱ-Ⅲ grade on ovarian serous cystadenocarcinoma was obviously higher than that in Ⅰ-Ⅱ stage and pathological Ⅰ grade (P<0.005～0.02).Conclusion It indicates that it should be diagnosed as epithelial ovarian carcinoma when the serum CA 125 >200～300u.ml -1 and it is helpful to differentiate histological type and predict prognosis of epithelial ovarian carcinoma by measuring CA 125 concentration in serum.
出处
《中国肿瘤临床与康复》
2002年第3期33-34,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
