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液压冲击脑损伤后细胞间粘附分子表达的研究 被引量：4

The experimental study of expression of intercellular adhesion molecule-1 after fluid percussion brain injury
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摘要 目的测定外伤性脑损伤后脑内细胞间粘附分子(ICAM-1)的变化。方法用大鼠液压冲击脑损伤致伤模型制作大鼠脑损伤,伤后2、4、8、12、24h取脑组织,用免疫组织化学方法染色并用MIAS图像分析系统进行图像分析。结果脑损伤后2h即可见ICAM-1在脑内表达上调,12h达高峰,24h已回落。结论测定I-CAM-1在脑内的变化情况,可为推断24h以内脑损伤形成时间及伤后存活时间提供参考。 Objective To determine the changes of intercellular adhesion molecule-1 after traumatic brain injury. Methods Use the fluid-percussion model to inflict rat brain and take the samples at 2?4?8?12?24 hours after brain injury. The samples were studied by immunohistochemistry method combined with image analysis by MIAS image analysis system. Result The expression of ICAM-1 upregulates at 2 hours, reaches peak at 12 hours and falls down at 24 hours after brain injury. Conclusion The changes of ICAM-1 in brain can provide a backup for estimation of injury time and survival period after brain injury which sustained within 24 hours.
作者 王欣 李梅 廖志钢 刘敏
机构地区 四川大学华西法医学院病理教研室
出处 《法医学杂志》 CAS CSCD 2002年第1期15-16,共2页 Journal of Forensic Medicine
关键词 脑损伤 细胞间粘附分子 免疫组织化学 图像分析 法医鉴定学 brain injury ICAM-1 immunohistochemistry image analysis
分类号 D919.4 [医药卫生—法医学]
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参考文献8

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二级参考文献1

共引文献3

同被引文献27

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法医学杂志
2002年 第1期

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