摘要
本文对106例确诊为原发性肝癌的病例进行了1:1配对病例-对照研究。结果表明:①病例组中硒低而铜高;锰、锌在病例与对照组间无显著差异。但低硒、高铜单独存在时其效应均较低。②蛋白质摄入量与肝癌发生呈密切负相关,并有明显剂量效应关系。③本文进一步证明了HBV感染与肝癌发病密切相关。④低硒、高铜、蛋白质摄入量低分别与HBV感染之间有协同作用,而与抗-HB_s之间有拮抗作用。
A 1: 1 matched case--control study was conductedin 106 cases with clinical diagnosis of PLC and 106controls. The results are as follows: In the hair ofcases, the mean of selenium was significantly lowerthan that of controls. But copper was higher Themean of Mn and Zn were the same as in caes andcontrols. High intake of protein was a protective fac-tor. A close negative correlation was found between theamount of protein intake and the risk of PLC andthere was a dose response relationship. The resultsfurther provide the information to support thehypothesis that PLC was closely related to HBV infec-tion. There was a synergic interaction betweenHBV infection and low selenium high copper low pro-tein intake, but an antagonistic interaction appeared be-tween anti--HIBs and the factors mentioned above.
出处
《西安医科大学学报》
CSCD
1991年第2期146-150,共5页
Journal of Xi'an Medical University(Chinese)
基金
1987年国家自然科学基金
关键词
肝肿瘤
病因
微量元素
营养因素
PLC
trace element
nutrition
HBV
multiple factor analysis
