摘要
探讨内镜下注射硬化剂联合皮下注射奥曲肽及口服心得安、硝酸甘油等药物治疗食道静脉曲张出血的近远期疗效。方法 :Ⅰ组 (2 2例 )在注射硬化剂前 10～ 30min皮下注射奥曲肽 0 .1mg ,后每 8h 1次 ,连用 3d改为心得安 10～ 40mg/d ,硝酸甘油 1.5～ 2 .0mg/d长期口服 ;Ⅱ组 (2 0例 )单独应用硬化剂治疗。观察 2组早期再出血率 (3d内 )及远期再出血率 (1年内 ) ,并经统计学处理。结果 :Ⅰ组早期再出血率 4.5 % ,明显低于Ⅱ组15 .0 % ;1年随访Ⅰ组再出血 2例 (9.0 % ) ,Ⅱ组 7例 (35 .0 % )。两组比较有显著差异。结论 :内镜下注射硬化剂联合药物治疗食道静脉曲张出血 ,不仅明显降低早期再出血率 ,还可显著降低 1年内远期再出血率。
Objective: To evaluate the short and long-term efficacy of endoscopic injection sclerotherapy combined with drugs on bleeding esophageal varices. Methods: 42 cases were randomly classified into two groups: group 1 (22 cases) and group 2 (20 cases). Group 1 was given Octreotide hypodermic injection not only at 10～30 min before endoscopic injection sclerotherapy but also q8h for 3 days. Then Propranolol 10～40mg/d and Nitroglycerin 1.5～2.0 mg/d were orally administrated for long-term maintenance. Group 2 only accepted endoscopic injection sclerotherapy. Results: Rates of short-term rebleeding (in 3 days) and one-year rebleeding in these two groups were 4.5%, 15.0% and 9.0%, 35.0%, respectively. There was significant difference between the two groups (P<0.01). Conclusions: Endoscopic injection sclerotherapy combined with drugs can remarkably increase the rate of hemostasis and decrease the rate of one-year rebleeding. It is an effective and safe treatment for bleeding esophageal varices.
出处
《中国内镜杂志》
CSCD
2001年第4期41-42,共2页
China Journal of Endoscopy
