摘要
目的 :探讨某市自来水有机提取物对小鼠的诱变性。方法 :采集淮河水源水、自来水厂滤池出水、氯化消毒自来水及大型贮水箱水各 2 0 0L。经吸附 ,提取有机物后予小鼠灌胃染毒 ,检测胸骨骨髓嗜多染红细胞微核率和精子畸形率 ,并作U检验。结果 :淮河水源水及氯化消毒的自来水均有一定的致突变性。毒性大小依次为氯化消毒的自来水 >贮水箱水 >水源水 >滤池出水。结论 :淮河水源水已受到有机诱变物的污染 ,混凝沉淀具有去除有机物、降低源水诱变性作用 ,而氯化消毒使水质的诱变性增高。
Purpose: To explore the mutagenicity of organic extracts of tap water in a certain city in mice. Methods: Each 200 L of water was collected separately from Huai river source water, water of clarifying filtration, chlorinated tap water and reservoir's water. After being adsorbed and concentrated, water samples were poured into mouse stomaches. Micronucleus frequency in mouse thoracic bone-marrow polychromatic erythrocyte (PCE) and sperm deformity rate were determined. Results: Mutagenicity of some degree were determined from Huai river source water and chlorinated tap water. The order of mutagenic intensity was as follows; chlorinated tap water>reservoir's water>source water>water of clarifying filteration. Conclusions: The source water was contaminated by organic mutagens. After coagulation and precipitation, mutagenicity of source water decreased because some mutagenic organic chemicals could be removed. While chlorination increased mutagenicity of tap water.
出处
《癌变·畸变·突变》
CAS
CSCD
2002年第2期112-114,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
水污染
有机提取物
诱变性
小鼠
water pollution
organic extract
mutagenicity
mouse
