摘要
目的 :研究血管紧张素 Ⅰ (2 10 )对大鼠急性心肌梗死后心肌转化生长因子 β1(TGF β1)及胶原 (Ⅰ、Ⅲ型 )表达的影响 ,探讨血管紧张素 Ⅰ (2 10 )抑制急性心肌梗死后心室重构的作用。方法 :成功复制雄性大鼠急性心梗模型。实验组给予口服血管紧张素 Ⅰ (2 10 ) 5 0pmol/(kg·d) ,对照组及假手术组给予同等剂量的蒸馏水 ,在 15d处死 ,用免疫组织化学方法检测缺血梗死区TGF β1及Ⅰ、Ⅲ型胶原表达。 结果 :实验组与对照组比较 ,TGF β1和Ⅰ、Ⅲ型胶原的表达明显减少 (P<0 .0 1) ;实验组、对照组与假手术组比较 ,则明显增加 (P<0 .0 1)。结论 :血管紧张素 Ⅰ (2 10 )通过抑制内源性TGF β1分泌 ,抑制胶原堆积和心室重构 。
Objective: Our aim was to determine whether angiotensin Ⅰ(2 10) could enhance the expressions of transforming growth factor β1(TGF β1) and collagen Ⅰ and Ⅲ in rats with acute myocardial infarction(AMI), whether it could play an important role in the process of left ventricular remodeling. Methods: Experimental group received angiotensin Ⅰ(2 10) 50 pmol/(kg·d) by mouth, control group and sham group received natrii chloridi of same dose. On the 15 th day, TGF β1 and collagen Ⅰ and Ⅲ were detected with immunohistochemical staining. Results: The TGF β1 and collagen I and III in experimental group were lower than those in control group (P<0.01). Those in experimental group and control group were higher than those in sham group (P<0.01). Conclusion: Angiotensin Ⅰ(2 10) may play a role in the process of left ventricular remodeling after acute myocardial infarction.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2002年第2期93-95,共3页
Journal of China Medical University
