摘要
目的 探讨青春型双歧杆菌的脂磷壁酸（ＬＴＡ）对ＭΦ功能的影响。方法 将ＬＴＡ注射于小鼠腹腔，分别采用中性红吞噬试验、ＭＴＴ法、小鼠胸腺细胞增殖法和ＥＬＩＳＡ法，检测ＭΦ的吞噬能力、能量代谢水平、ＩＬ－ｌ的活性及ＩＬ－６含量。结果ＬＴＡ注射组小鼠腹腔ＭΦ的吞噬能力。能量代谢水平、ＩＬ－１活性及ＩＬ-６含量均显著高于对照组（Ｐ＜００１）。结论 双歧杆菌的ＬＴＡ能激活ＭΦ，提高其吞噬能力和能量代谢水平，同时可分泌多种的具有杀瘤作用的活性因子。
Aim To explore the influence of lipoteichoic acids (LTA) of bilidobacteria adolescence on the function of macro- phages. Methods The phagocytosis ability, energy metabolism level , IL- 1 activity and IL- 6 level of mouse macrophages perito- neal fluid from the mouse injected with LTA of bifidobacteria were detected by neutral red phagocytosis test, MTT method, mouse thymocyte proliferation test and ELISA respectively. Re- suits The phagocytosis ability, energy metabolism level, IL- 1 activity and IL- 6 level of mouse peritoneal macrophages in LTA injection group were significantly higher than those in the control group( P <0.01). Conclusion Lipoteichoic acids of bifidobac- teria can activate macrophages to secrete many kinds of active factors with tumoricidal activiy, and enhance its phagocytosis a- bility and energy metabolism level.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2002年第1期23-25,共3页
Chinese Journal of Cellular and Molecular Immunology
关键词
双歧杆菌
脂磷壁酸
巨噬细胞
bifidobacterium
lipoteichoic acid
Macrophage
