摘要
目的 :探讨血清胆红素的强抗氧化性质 ,研究胆红素及氧化修饰低密度脂蛋白 (OX LDL)与冠心病的关系。方法 :对冠心病组 (6 0例 )、对照组 (30例 )的血清总胆红素、直接胆红素、间接胆红素及OX LDL、胆固醇、甘油三酯、低密度脂蛋白胆固醇 (LDL C)进行测定 ,并将两组结果进行比较。结果 :冠心病组的总胆红素、直接胆红素及间接胆红素均低于对照组 (P <0 .0 5 ) ,冠心病组的OX LDL及LDL C较对照组增高 (P <0 .0 5 )。结论 :血清胆红素浓度降低使体内抗氧化活性减弱 ,可能引起低密度脂蛋白氧化修饰形成OX LDL增多 ,从而促使冠心病的形成。
Objective:To study the antioxygenic activity of bilirubin and the association of serum concentration of bilirubin and oxidatively modified low density lipoprotein (OX LDL) with coronary heart disease.Method: Serum bilirubin was determined with Malloy Evelyn. OX LDL was determined with ELISA. Total cholesterol (TC) and triglycerides (TG) were determined with enzymology, high density lipoproteins cholesterol (HDL C) was determined with elimination enzymatic assay, low density lipoprotein (LDL C) was calculated with Friedward formula.Result: The concentration of total bilirubin and indirect bilirubin in coronary heart disease were lower than those in the controls (P< 0.05 ). The concentration of OX LDL and LDLC in coronary heart disease were higher than those in the controls (P> 0.05 ).Conclusion: Lower serum bilirubin concentration possibly reduce the activities of antioxidant. It is possible to expedite that low density lipoprotein peroxidation and lower serum bilirubin is associated with increased risk for coronary heart disease.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第5期204-206,共3页
Journal of Clinical Cardiology
基金
福建省教育厅科研基金资助项目 (No .JA0 0 0 2 5 )
福建省卫生厅青年基金资助课题 (99 0 1 19)
关键词
胆红素
冠心病
脂蛋白类
低密度
冠状动脉疾病
Bilirubin
Oxidatively modified low density lipoprotein
Coronary disease
