摘要
目的 :探讨人脑膜瘤碱性成纤维细胞生长因子 (b FGF)的表达与肿瘤血管生成和细胞增殖能力的关系。方法 :应用免疫组织化学方法检测了 3 8例脑膜瘤组织 b FGF表达 ,分析其与肿瘤微血管形成及细胞增殖能力的关系。结果 :b FGF阳性表达率和表达强度在良性、非典型和间变型脑膜瘤间均无明显差异 (P>0 .0 5 )。良性与非典型脑膜瘤微血管密度 (MVD)值差异不显著 ,而间变型脑膜瘤 MVD值明显高于前二者 (P<0 .0 1 )。 b FGF表达阳性与表达阴性肿瘤的 MVD值差异无显著意义。三类脑膜瘤 b FGF表达分值与 MVD值及与 PCNA LI均不相关 (P>0 .0 5 )。结论 :未发现脑膜瘤 b FGF表达与血管生成存在明显的关系 ,在脑膜瘤血管生成和细胞增殖能力中 b
Objective: To investigate relationship between the expression of basic fibroblast growth factor (bFGF) and both angiogenesis and cell proliferative potential in human meningiomas. Methods: bFGF expression, vascularization and tumor cell proliferative potential were analyzed in 38 specimens of human meningioma (14 bening, 12 atypical and 12 anaplastic) using immunohistochemistry. Results: There was no significant difference in bFGF positive expression rates and bFGF expression intensities between benign and atypical meningioma or atypical and anaplastic meningiomas ( P >0.05). No significant difference in microvessel density (MVD) was detected between benign and atypical meningiomas, whereas MVD in anaplastic tumors was markedly higher than that in benign or atypical tumors ( P <0.01). The difference in MVD was not significant between bFGF positive and bFGF negative tumors( P >0.05). The expression of bFGF in meningioma tissues was not correlated with both MVD and proliferating cell nuclear antigen labeling index (PCNA LI) ( P >0.05). Conclusion: No relationship was found between bFGF expression and meningioma vascularity. It is no evident for bFGF to be related with agionesis and cell proliferation of meringioma.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2002年第3期266-269,共4页
Journal of Jilin University：Medicine Edition
