摘要
目的 :探讨持续性植物状态 (PVS)患者血浆和脑脊液 (CSF)中单胺类递质水平与PVS发病的关系。方法 :采用高压液相色谱 (HPLC)方法测定。结果 :PVS患者血浆中多巴胺 (DA)的含量 (μmol/L)为 1.95± 0 .99,较对照组(1.16± 0 .4 7)显著升高 (P <0 .0 5 ) ,而 5 羟色胺 (5 HT)、酪氨酸 (TYR)、色氨酸 (TRP)、γ 氨基丁酸 (GABA)的含量(μmol/L)较对照组均无显著差异 (P均 >0 .0 5 )。脑脊液中 ,DA较对照组无显著差异 ;5 HT的含量 (μmol/L)为 (0 .4 9± 0 .32 ) ,较对照组 (1.0 2± 0 .35 )显著降低 (P <0 .0 5 ) ;而TYR(1.36± 0 .11)、TRP(0 .6 3± 0 .4 0 )、GABA(1.15±0 .6 1)的含量分别较对照组 (0 .4 0± 0 .2 4、0 .2 9± 0 .2 2、0 .37± 0 .4 5 )有显著升高 (P <0 .0 5、P <0 .0 5、P <0 .0 1)。血浆中GABA与DA的含量呈相关性 (P <0 .0 5 )。脑脊液中GABA与DA的含量也呈相关性 (P <0 .0 1)。结论 :CSF中 5 HT下降和血浆中DA升高可能与PVS的发生和发展过程有关。
Aim: To study the relationships between the pathogenesis of persistent vegetative state(PVS) and the levels of monoamine neurotransmitters in plasmas and cerebrospinal fluids(CSFs) in patients with PVS. Methods:The high pressure liquid chromatography(HPLC) was used to detect. Results: It was found that the level of dopamine(1.95±0.99) was significantly increased in plasma compared with the control(1.16±0.47)( P <0.05),but the levels of 5 HT,TYR,TRP, GABA of plasma were insignificantly changed. In cerebrospinal fluid, the level of DA was insignificantly changed, and the level of 5 HT (0.49±0.32) was significantly decreased compared with the control(1.02±0.35) ( P <0.05), but the levels of TYR(1.36±0.11), TRP(0.63±0.40), GABA(1.15±0.61) were significantly increased respectively compared with the controls(0.40±0.24; 0.29±0.22; 0.37±0.45) ( P <0.05; P <0.05; P <0.01). The levels of GABA and DA in plasma were significanly correlated ( P <0.05),and GABA and DA in CSF were also significanly correlated ( P <0.01). Conclusion: The results of this study suggested that PVS is related to the decrease of 5 HT in CSF and the increase of DA in plasma.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2002年第2期136-138,共3页
Chinese Journal of Applied Physiology
基金
海军后勤卫生部资助项目 (973 3 0 3 )
