摘要
目的:探讨血瘀证的证型实质。方法:检测216例冠心病血瘀证患者高切速全血粘度(ηHB)、低切速全血粘度(ηLB)、血浆粘度(ηP)、红细胞聚集指数(AI)、红细胞压积(HCT)及血清总胆固醇(CH)、甘油三酯(TG)、血浆纤维蛋白原(Fb)、前列环素(PGI_2)、血栓素(TXA_2)的浓度。结果:气滞血瘀组ηLB、A显著升高,PGI_2/TXA_2明显下降,血液呈高聚状态;阴虚血瘀组CH、HCT、Fb、AI、ηLB明显增高,血液呈高浓、高凝、高聚状态;痰浊血瘀组ηLB、ηP、TG显著升高,血液里高粘状态;气虚血瘀组仅ηHB有所升高,其他指标变化不明显。结论:提示血瘀证的不同证型有不同的生化物质基础,血液理化特性变化与中医证型关系密切。为血瘀证进一步分型论治提供了实验依据。
Objective: To probe into essence of syndrome types of blood stasis syndrome. Methods: High shearing whole blood viscosity (ηHB). low shearing whole blood viscosity (ηLB), plasma viscosity (ηP), aggregation index of erythrocyte (AI), hematocrit (HCT) and levels of serum total cholesterol (CH), triglyceride (TG), plasma fibrinogen (Fb), prostacyclin (PGI2), thromboxane (TXA2) were determined in 216 cases of coronary heart disease with blood stasis syndrome. Results: ηLB and AI increased and PGI2/TXA2 ratio decreased significantly in the group of stagnation of Qi and stasis of blood, showing high aggregation state of blood: CH, HCT, Fb, AI and ηLB increased significantly in the group of blood stasis due to Yin -deficiency, showing high concentration, high agglutination and high aggregation state of blood : ηLB, ηP and TG increased significantly in the group of stagnation of phlegm and blood, showing high viscosity state of blood; only ηHB had some increase in the group of Qi - deficiency and blood stasis . Conclusion: Different syndrome types of blood stasis syndrome
have different biochemical material base, and changes of blood physical and chemical properties are closely related with TCM syndrome types, which provides an experimental basis for treatment of subtypes of blood stasis syndrome.
出处
《中医杂志》
CSCD
北大核心
2002年第5期378-379,共2页
Journal of Traditional Chinese Medicine
关键词
辨证分型
冠心病
血瘀证
血液理化特征
Coronary artery diseases/blood, blood stasis/ blood, types of syndrome
