摘要
目的 对比观察干扰素不同剂量、不同给药间隔时间对尖锐湿疣 (CA)的疗效。方法 应用干扰素 1 0 0万 u隔天 1次 (A组 )、3 0 0万 u隔天 1次 (B组 )、1 0 0万 u每周 1次 (C组 )、3 0 0万 u每周 1次 (D组 ) ,共 6次治疗 1 1 0例 (CA)患者 ,同时采用双抗体夹心 ELISA法测定 (CA)患者治疗前后血清白介素 - 2(IL- 2 )水平。结果 所有患者 IL- 2水平均低于正常 ,A组、B组治疗后血清 IL- 2水平无明显变化 (P >0 .0 5 ) ,A组与 B组、C组与 D组之间的复发率无差别 (P >0 .0 5 ) ;C组、D组的 IL- 2水平上升显著 (P <0 .0 1 ) ,A组与 C组、B组与 D组之间的复发率差异有显著性 (P <0 .0 1 )。结论 干扰素小剂量长时间作用能有效降低 CA的复发率 ,其预防
Objective To study the effects of interferon with different dose and time for adminstration on condyloma accuminatior(CA) Methods 110 patients with CA were administered with interferon,which was given for 6 times in four methods:group A 1000,000IU,qod;group B 3000,000IU,qod;group C 1000,000IU/week;group D 3000,000IU/week.Serum inlerteukin 2(IL 2) was measured before and after treatment by double antibody layered ELISA Results IL 2 was lower in patients with CA than normae controls.IL 2 did not change significantly after treatment in group A and B (P>0 05).There were not significanty different in relapse rate between group A and B,group C and D (P>0 05),But relapse rate were significently different between group A and C,group B and D (P<0 01) Conclusions The lower dose and longer time treatment with interferon could lower the relapse rate of CA.The key for prevent CA relapse is to increase the effecting time
出处
《医学文选》
2002年第2期147-148,共2页
Anthology of Medicine
关键词
尖锐湿疣
干扰素
白介素-2
治疗
Condyloma accumination
interferon
interleukin 2
treatment
