摘要
根据药效团模型 ,合理设计并合成了新型光系统Ⅱ (PSⅡ )抑制剂化合物 ,进行了元素分析和红外、紫外及核磁数据表征 .希尔反应测试表明 ,所合成的化合物均具有抑制光系统Ⅱ电子传递功能的生物活性 ,有的化合物活性较高 ,为新型PSⅡ除草剂的开发显示了广阔的应用前景 .
According to the pharmacophore model, a series of new type photosystem Ⅱ (PSⅡ) inhibitors were designed, synthesized and characterized with element analysis, UV, IR and 1H NMR spectra. The biological activities of the new PSⅡ inhibitors by Hill reaction showed that they all presented the biological activities of blocking electron transport in photosystem Ⅱ. The biological activities of some compounds were so high that they could be applied in the future as PSⅡ herbicides.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2002年第3期487-492,共6页
Acta Chimica Sinica
基金
天津市教育委员会自然科学基金 (No .972 0 2 )资助项目
关键词
光系统Ⅱ抑制剂
分子设计
合成
生物活性
除草剂
molecular design, synthesis, photosystem Ⅱ, biological activities, herbicides
