摘要
以光系统Ⅱ抑制剂DISCO(DIStance COmparisons)模型的活性构象分子作为模板,利用比较分子场分析方法对三类结构不同的化合物进行了三维构效关系的研究。研究结果有助于对DISCO重叠模型的评估和新型PSⅡ抑制剂的设计与合成。
According to the comparative molecule field analysis (CoMFA) ,3D - quantitative structure - activity relationships (3D - QSAR) of three series of different structural compounds were undertaken with the active conformers of the molecules chosen from DISCO (DIStance Comparisons) alignment model of different structural photosystem II compounds as the templates. The results can be used to evaluate the reasonableness of the DISCO model and corresponding active conformation for the studied compounds, and to produce some clues for the design of new PSII inhibitors.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第4期564-569,共6页
Chinese Journal of Organic Chemistry
基金
天津市教育委员会资助课题(项目号97202)
