摘要
磷酸钙陶瓷植入体内后其表面类骨磷灰石层的形成是诱导成骨的先决条件.本实验在模拟体液(simulated body fluid, SBF)以人体骨骼肌组织内体液的正常生理流率(2mL/100mL.min)和偏离正常生理流率流动的动态条件下,研究在动态SBF中影响致密磷酸钙陶瓷表面类骨磷灰石层形成的因素.结果表明:在生理流率条件下,材料的粗糙表面有利于类骨磷灰石的形成,加大SBF中Ca2+、HPO2-4离子浓度,类骨磷灰石层的形成速度加快.比起通常使用的静态浸泡试验,SBF以生理流率流动的动态试验能够更好地模拟类骨磷灰石生长的体内环境.动态SBF对了解类骨磷灰石形成,进而了解磷酸钙陶瓷在体内诱导成骨机理是十分有用的.
Bone-like apatite formation on the surface of calcium phosphate ceramics has been believed to be the necessary step that new bone grows on the ceramics and to be relative to the osteoinductivity of the material. The research of the factors effecting bone-like apatite formation is a great help to understanding the mechanism of osteoinduction. This study was a comparative study of in vitro formation of bone-like apatite on the surface of dense calcium phosphate ceramics with SBF flowing at different speeds. The results showed that the rough surface was beneficial to the formation of bone-like apatite and the apatite formed faster in 1.5 SBF than in SBF. Rough surface, namely, larger surface area, increased the dissolution of Ca2+, HPO42- and higher concentration of Ca2+ and HPO42- ions of SBF was advantageous to the accumulation of Ca2+, HPO42-, pO(4)(3-) near the ceramic surface. Local supersaturating concentration of Ca2+, HPO42-, PO42- near sample surface was critical for nucleation of apatite on the surface of sample.
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2002年第3期552-558,共7页
Journal of Inorganic Materials
基金
国家重大基础研究项目(973G1999064760)
