摘要
目的 :考察不同制药厂感冒清片的溶出度 ,评价其内在质量。方法 :采用高效液相色谱法测定对乙酰氨基酚含量 ,色谱柱为Nova -PakC18 或SpherecloneODS(2) ,流动相为甲醇 -水 (1∶3) ,检测波长为249nm ,流速为0.5ml/min ;溶出度采用转篮法。结果 :该法能理想地测定感冒清片中对乙酰氨基酚含量 ,8批样品体外溶出差异大。结论 :本方法简便、快速、可靠 ,建立该制剂的溶出度标准是非常必要的。
OBJECTIVE:To determine the dissolubility of paracetamol in Ganmaoqing tablets produced by different manufactories and to evaluate the internal qualities METHODS:The content of paracetamol in Ganmaoqing tablets was determined by HPLC with Nova-Pak C18 or Sphereclone ODS(2) column as fixed phase and methanol-water(1∶3) as mobile phase Paracetamol was detected at 249 nm with UV detetor The flow rate was 0 5ml/min Rotating basket method was used in dissolution test RESULTS:The method could determine the content of paracetamol in Ganmaoqing tablets satisfactorily The dissolution rates of eight samples were quite different CONCLUSION:The method is simple,rapid and reliable It is very necessary to establish the dissolubility standard for Ganmaoqing tablets
出处
《中国药房》
CAS
CSCD
2002年第4期236-237,共2页
China Pharmacy
