摘要
Toll样受体 (Toll likereceptors,TLRs)是新近发现的先天性免疫系统中的细胞跨膜受体及病原模式识别受体之一 ,在急性炎症反应细胞吞噬作用的调节和细胞信号转导及细胞凋亡中起重要作用 .简要综述了Toll样受体的发现、分布、基因定位与结构特点、配体特异性及其介导的信号通路 。
Toll-like receptors,a kind of trans-membrane receptors and pathogen pattern recognition receptors, play important roles in regulating cytophagy, signal transduction and apoptosis during an acute inflammation. Their discovery,distribution,gene locus,structure, ligands specificity and signaling pathway were reviewed and also their research importance and developing trends in the future were briefly discussed.
出处
《生命科学研究》
CAS
CSCD
2002年第1期36-39,共4页
Life Science Research
基金
国家自然基金资助项目 ( 39730 2 10 )
