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豚鼠-大鼠异种异位心脏移植模型的建立 被引量:5

A model of guinea-pig to rat heart heterotopic xenotransplantation established
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摘要 目的 建立简便易行的异种心脏异位移植动物模型。方法 采用改良Ono术式行豚鼠 大鼠异种异位心脏移植。结果 进行正式实验 6 0例 ,成功率为 90 % ,移植后平均存活时间为 (30± 8)min ,主要失败原因为麻醉意外、吻合口出血。结论这种模型操作简便 ,重复性好 ,适合研究选用。 Objective To establish a simple heart heterotopic xenotransplantation animal model. Methods Guinea pig to rat heterotopic cardiac transplantation were performed using modified Ono procedure. Results Rate of success was 90%.Mean survive time was (30±8)min.The failure reasons included anastomotic bleeding and anesthetic accident. Conclusion This model proves to be relatively simple,stable and practicable, to be used in experimental study .
作者 李军 杨康
出处 《重庆医学》 CAS CSCD 2002年第5期357-358,共2页 Chongqing medicine
关键词 异种移植 心脏移植 豚鼠 大鼠 异位移植 动物模型 xenotransplantation heart guinea pig rat model
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