摘要
目的 :观察醋酸曲安奈德鼻喷剂长期应用对鼻粘膜和鼻纤毛有无损害作用。方法 :杂色犬 12只 ,高剂量组、低剂量组及对照组各 4只。高剂量组采用 0 .6 4 %醋酸曲安奈德鼻喷剂 ,每日 1次 ,每次 2个鼻孔各喷药 1次 (880 μg) ;低剂量组采用0 .14 %醋酸曲安奈德鼻喷剂 ,每日 1次 ,每次 2个鼻孔各喷药 1次 (2 2 0 μg) ;对照组采用 0 .9%NaCl,每日 1次 ,每次 2个鼻孔各喷 10 0 μl。用药前后观察鼻腔粘膜、血常规 ;用药后 ,光镜和电镜观察鼻粘膜。结果 :用药后 ,鼻粘膜、血常规均正常 ,三组间无差异 ,光镜和电镜下未见鼻粘膜病损。结论
Objective:To explore the effects of triamcinolone acetonide acetate nasal spray on the animal's nasal mucosa.Method: Animals were divided into three groups: group one for high dosage; group two for low dosage; group three for control. Animals were given the high dosage of triamcinolone acetonide acetate nasal spray (880 μg), low dosage of triamcinolone acetonide acetate nasal (220 μg), 0.9 % saline solution spray for each nasal cavity for two months. Before and after drug spraying, the examination of nasal mucosa and the blood routine were made, and the middle and inferior turbinate were removed for light and electron microscopic examination.Result: No differences of blood routine and nasal mucosa can be seen among the three groups, and the light and electron microscopic examination also.Conclusion: No harmful effects of triamcinolone acetonide acetate nasal spray on the nasal mucosa for long time using can be seen on the animal's experiment.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2002年第5期232-233,共2页
Journal of Clinical Otorhinolaryngology
关键词
醋酸曲安奈德鼻喷剂
变应性鼻炎
糖皮质激素类
Triamcinolone acetonide acetate nasal spray
Allergic rhinitis
Glucocorticoids
