摘要
目的 观察猕猴眼内氟 肝素表面修饰的人工晶状体 (intraocularlens ,IOL)表面细胞的反应情况 ,研究修饰后IOL的生物相容性。方法 健康猕猴 10只 (2 0只眼 )分为修饰和未修饰两组 ,分别植入氟 肝素表面修饰和未修饰的IOL。于术后 180d和 36 0d对取出的IOL进行光镜、扫描电镜及计算机图像分析。结果 IOL光学中心表面黏附细胞较少 ,周边部黏附细胞较多。细胞黏附面积最大者为巨细胞 ,数量最多者为巨噬细胞。修饰组IOL表面黏附细胞少于未修饰组 ;修饰的IOL表面附着细颗粒样的蛋白膜 ,未修饰的IOL表面附着纤维网状及颗粒样的蛋白膜。结论 氟
Objective To study the biocompatibility of F heparin surface modified intraocular lenses (IOLs) by observing cellular reaction on the surface of IOLs implanted into the rhesus monkeys′ eyes Methods Ten monkeys (20 eyes) were classified into two groups PMMA IOLs and F heparin modified IOLs were respectively implanted into 10 monkeys′ eyes The IOLs were examined with computer image analysis, light microscope (LM) and scanning electron microscope (SEM) at postoperative 180 and 360 days Results A few of adhered cells were on the surface of the central part of the IOL and more on the border of the IOL optics The giant cells deposited on the surface occupied the largest area and the number of the macrophages was the greatest The cells deposited on the surface of the IOLs in the F heparin modified group were less than that in the non modified group In the modified group, there was fine granular proteinaceous membrane on the surface of the IOLs, but in the non modified group there was fibrinous reticular proteinaceous membrane Conclusion The biocompatibility of the F heparin surface modified IOLs is better than that of non modified PMMA IOLs
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2002年第3期154-156,共3页
Chinese Journal of Ophthalmology
