摘要
目的:研究下呼吸道标本分离的绿脓假单胞菌经环丙沙星(CPLX)次抑菌浓度(1/2MIC)诱导后对诺氟沙星(NFLX)等喹诺酮类药物以及非同类抗菌药物是否交叉耐药,为临床合理用药提供依据。方法:用1/2MIC CPLX诱导绿脓杆菌9d后,测定其对各抗菌药物的敏感性。结果:诱导后绿脓杆菌对CPLX纸片法的平均抑菌直径比诱导前小11mm,对于IMP和AMK纸片法,诱导前后的平均抑菌环直径未见变化。诱导后绿脓杆菌对CPLX、NFLX、PFLX和FLOX的MIC值分别是诱导前的4-16、4-16、4-16和4-32倍。结论:临床应用CPLX治疗绿脓杆菌感染时应注意剂量和疗程,避免因药物达不到有效的治疗浓度而导致治疗失败和耐药菌株的产生。
Objectives: To study whether P. aeuginose, which was isolated from the specimen of lower respiratory tract and induced through ciprofloxacin(CPLX)subinhibitory concentration(1/2MIC) had occured cross-resistance to quinoloncs as CPLX and other type of antibacterial drugs. Method: The sensitivities of various antibacterial drugs were determined after the P.aecginose induced with 1/2 MIC of CPLX for 9 days. Result: The diameter of mean bacterial inhibition zone after induced by CPLX disk was 11 mm smaller than that before induced, the diameters of mean bacterial inhibition after induced through IMP and AMK disk and that before induced were unchanged. The MICs of P. aeughio.se against CPLX, NFLX, PFLX, and FLOX after induced were 4-16, 4-16, 4-16, and 4-32 times before induced. Conclusion: Dosage and therapy duration should be cared when CPLX is used in the treatment of P. aeuginose infection, drug therapy concentration of no effect should be avoided, because it will result in the therapy failed of success and the drug resistant strains emerage.
出处
《中国药师》
CAS
2002年第1期11-13,28,共4页
China Pharmacist
关键词
绿脓杆菌
环丙沙星
次抑菌浓度
耐药
药敏试验
抗生素
P. aeruginose
Ciprofloxacin
Subinhibilory concern ration
Resistance, induced
Resistance, cross
