摘要
为探讨粘附分子P选择素 (CD6 2P)在原发性肾病综合征 (NS)患者中的致病作用及其与肾组织各种病理类型的关系 ,以肾穿刺活检法取NS患者肾组织 ,采用直接免疫荧光标记单克隆抗体 ,周围血采用流式细胞术的方法 ,进行了CD6 2P表达的研究。结果显示 ,16 5例NS患者肾组织中有CD6 2P表达 14 0例 (84 8% ) ,以MPGN、MsPGN表达显著 ,MN、FSGS次之 ,MCD最弱 ;NS患者周围血CD6 2P表达量较正常对照组明显增高 (P <0 0 1) ;CD6 2P在肾组织的表达与周围血表达水平密切相关 ,且与肾脏各种病理类型的病变部位一致。提示CD6 2P在NS发病机制中具有重要作用。
The aim of this study was to investigate the role of adhesion molecules P selectin (CD62P) in the pathogenesis of primary nephrotic syndrome (NS) and its relationship with its different pathological types. The expression of CD62P in renal biopsy tissue and peripheral blood platelets from patients with NS were measured with direct immunofluorescence labelling monoclonal antibody and flow cytometry respectively. The results showed that CD62P was expressed in 140/165 cases with NS (84 8%). Among these patients, renal expression of CD62P was lower in MN and FSGS patients than that in MPGN and MsPGN patients, and even lower in MCD patients. The expression of CD62P in peripheral blood platelets of patients with NS was significantly higher than that in the normal control group( P <0 01); It was also noted that there were significant correlations between CD62P expression in renal tissues and that in peripheral blood platelets of patients with NS. Similar results were also obtained between CD62P expression in the affected areas in the kidneys of different pathological types.These results suggested that CD62P might play an important role in the pathogenesis of primary NS.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2002年第4期369-370,共2页
Medical Journal of Chinese People's Liberation Army
