摘要
目的 评价肿瘤坏死因子α(TNF α)、白细胞介素 2 (IL 2 )瘤内注射联合全身化疗对晚期非小细胞肺癌的近期治疗效果。方法 5 4例初治晚期非小细胞肺癌病人随机分为两组 ,其中治疗组 2 7例采用TNFα和IL 2瘤内注射联合全身化疗 ,对照组2 7例采用单纯全身化疗。结果 对照组部分缓解 (PR) 11例 ,肿瘤进展 (PD) 2例 ,总有效率为 4 0 7% ;治疗组PR18例 ,无 1例PD ,总有效率 6 9 2 % ,高于对照组 (P <0 0 5 )。结论 TNFα和IL
Objective To evaluate the short term effect of tumor necrosis factor α(TNFα) and Interleukin 2(IL 2) combined with systemic chemotherapy.Methods 54 cases of advanced non small cell lung carcinoma were divided into two groups randomly. Therapy group of 27 cases received intratumoral injection of TNFα and IL 2 combined with systemic chemotherapy. Controlled group of the other 27 cases received systemic chemotherapy only.Results Partial remission(PR) of controlled group was observed in 11 cases. There are 2 patients in progressive disease(PD).Total effective rate(PR+CR) was 40.75%. PR in 18 cases of therapy group was observed and PD in no one case. Total effective rate was 69.2% and was significantly higher than that of controlled group( P <0 05). Conclusion Intratumoral injection of TNFα and IL 2 combined with systemic chemotherapy could improve short term effect of chemotherapy of patients with advanced non small cell lung carcinoma and have no significant side effects.
出处
《重庆医学》
CAS
CSCD
2002年第4期264-265,共2页
Chongqing medicine
关键词
细胞因子
化疗
治疗
晚期非小细胞肺癌
疗效观察
药物疗法
联合治疗
tumor necrosis factor α
interleukin 2
non small cell lung carcinoma/drug therapy
lung neoplasms/drug therapy
