期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

苯中毒患者外周血淋巴细胞染色体畸变分析 被引量：2

暂未订购
导出
摘要 用 G分带技术及标准的微量全血培养法检测苯中毒工人外周血淋巴细胞染色体结构畸变及数目畸变。中毒组的染色体结构畸变率与对照组的比较未显示差异 ,但结构畸变类型出现特异性改变。染色体数目畸变率及其中亚二倍体率中毒组均明显高于对照组。苯中毒患者是苯致白血病的高危人群 ,深入研究染色体畸变在苯诱导白血病过程中的作用 ,对筛选高危职业人群有很重要的意义。
作者 高耘 邢彩虹 戴宇飞 张林林 李桂兰
机构地区 中国预防医学科学院劳动卫生与职业病研究所
出处 《中国卫生监督杂志》 2002年第2期81-84,共4页 Chinese Journal of Health Inspection
关键词 G分带技术 微量全血培养法 白血病 苯中毒 外周血 淋巴细胞 染色体畸变
分类号 R135.12 [医药卫生—劳动卫生]
  • 相关文献

参考文献6

  • 1Maria Sasiadek. Monrandom distribution of breakpoints in the karyotypes of workers occupationally exposed to benzene[J]. Environmental Health Perspectives, 1992,97 : 255.
  • 2Zhang L,P.,Rothman N. ,Wang Y. X. ,et Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene[J]. Carcinogenesis, 1998,19:101.
  • 3Ellen Solomon, Julian Borrow, Audrey D. Coddard. Chromosome aberrations and cancer[J]. Science, 1991,254: 1153.
  • 4邵建华,张罗平.应用荧光原位杂交技术探测苯代谢产物的遗传毒性[J].中国工业医学杂志,1998,11(2):73-76. 被引量：6
  • 5胡斌,曹佳,程天民.荧光原位杂交和抗着丝粒抗体染色技术对氢醌非整倍体的毒性研究[J].卫生毒理学杂志,1998,12(2):94-95. 被引量：3
  • 6Berrin Tunca,Unal Egeli. Cytogenetic findings on shoe workers exposed long-term to benzene [J]. Environment Health Perspective, 1996,104:1313.

二级参考文献1

共引文献6

同被引文献33

  • 1桂红星 程文英 等.GPA突变分析在辐射生物剂量学中的研究现状[J].国外医学：放射医学核医学分册,1996,20(5):227-230.
  • 2Yin SN, Hayes RB, Linet MS, et al. An expanded cohort study of cancer among benzene-exposed workers in China. Benzene Study Group. Environ Health Perspect, 1996,104:1339-1341.
  • 3Yin SN, Hayes RB, Linet MS, et al. A cohort study of cancer among benzene-exposed workers in China : overall results. Am J Ind Med, 1996,29 : 227-235.
  • 4Haynar L,Brogger A,Hansteen IL, et al. Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes:Nordic study group on the health risk of chromosome damage. Cancer Res, 1994,54:2919-2922.
  • 5Bonassi S, Abhondandolo A, Camurri L, et al. Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet Cytogenet, 1995,79 : 133-135.
  • 6Hagmar L, Bonassi S, Stromberg U, et al. Chronmsomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res,1998,58:4117-4121.
  • 7Hagmar L, Bonassi S, Stromberg U, et al. Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health. Murat Res, 1998,405: 171-178.
  • 8Lando C, Hagmar L, Bonassi S. Biomarkers of cytogenetic damage in humans and risk of cancer. The European Study Group on Cytogenetic Biomarkers and Health(ESCH). Med Lay, 1998,89:124-131.
  • 9Bonassi S, Hagmar L, Stromberg U, et al. Chromosomal aberrations in lymphocytes predict human cancer independently d exposure to carcinogens. European Study Group on Cytogenetic Biomarkers and Health.Cancer Res,2000,60:1619-1625.
  • 10Liou SH, Lung JC, Chen YH, et al. Increased chromosome-type chromosome aberration frequencies as biomarkers of cancer risk in a blackfoot endemic area. Cancer Res, 1999,59 : 1481-1484.

引证文献2

二级引证文献7

中国卫生监督杂志
2002年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部