摘要
目的:观察癫痫患者在长期服用抗癫痫药物期间的血药浓度、疗效和严重的不良反应。方法:采用美国产全自动荧光免疫偏振分析仪和相应的试剂药盒对本市可评价的213例癫痫患者进行血药浓度监测,并观察各种抗癫痫药物的疗效和严重不良反应。结果:卡马西平、丙戊酸、苯妥英、苯巴比妥和氯硝西泮分别有95.7％、45.8％、30.4％、80.5％和70.3％例次在有效治疗血药浓度范围中;严重不良反应较少见;卡马西平和丙戊酸疗效较佳,苯妥英疗效较差。结论:卡马西平(除婴儿痉挛外)和丙戊酸宜作为癫痫患者的首选药物,血清浓度分别宜控制在6～8μg/ml和60～90μg/ml。苯妥英不宜用于癫痫的治疗。
Objective: To investigate the serum concentrations, efficacy and adverse effects of antiepileptic drugs in patients with epilepsy during long - term treatment. Methods: The serum concentrations of antiepilepi in drugs in a total of 213 patients with epilepsy were measured by fluorescence polarization immunoassay, the clinical efficacy and serious adverse effects were observed. Results: Within the effective therapeutic concentration ranges were 95.7% , 45.8% , 30.4% . 80.5% and 70.3% patients with the treatment of carba-mazepine, valproicacid, phenytoin, phenobarbial and clonazepam respectively. The serious adverse effects were few. The clinical efficacy of carbamazepine and valproic acid was better than the other antiepileptic drugs, the clinical efficacy of phenytoin was worse. Conclusion: carbamazepine (except for infantile spasms) and valproic acid should be the first line drugs in the treatment of patients with epilepsy, the best serum therapeutic concentrations are 6 - 8μg/ ml and 60 -90μg/ ml respectively. Phenytoin should not be used in patients with epilepsy generally.
出处
《中国医药导刊》
2002年第2期136-137,共2页
Chinese Journal of Medicinal Guide
关键词
癫痫
抗癫痫药物
药物监测
不良反应
血药浓度
epilepsy
antiepileptic drugs
therapeutic drug monitoring
adverse effects
