摘要
目的探讨畸形性骨炎的临床特点及诊断方法。方法3例患者,均为男性;年龄分别为51、49、43岁;2例病变发生在骨盆,以髋关节疼痛、不适就诊,1例发生在左侧胫骨,以胫骨弓状畸形就诊。X线检查示骨小梁粗大稀疏,密度不均,排列紊乱,条索状高密度影交织呈网格状改变。3例患者均行穿刺活检,病理表现为骨小梁增宽,可见不规则的骨粘合线,成骨细胞及破骨细胞活跃,骨髓被纤维组织和血管替代。明确诊断后给予降钙素和二膦酸盐等药物治疗。结果3例患者均获随访,随访时间3～26个月,平均16个月。所有患者症状和体征均未加重,能继续从事原工作,X线片复查未见明显变化。结论畸形性骨炎是一种骨代谢异常疾病,有时患者的骨改变特别明显,而临床表现并不突出。典型的放射学检查和病理学表现是诊断畸形性骨炎的重要依据。
Objective To investigate the clinical manifestation and diagnosis of osteitis deformans. Methods Three male patients with characteristic manifestations of osteitis deformans were reviewed in this study. The ages of the patients were 51, 49 and 43 respectively. Two patients with pelvic lesions on X ray films presented symptomatic pain and malaise localized in hip, one complained of tibial bowing deformity. The typical radiographic characteristics were bone enlarged size, increased bone mineral density with uneven distribution; the bone trabeculae were usually coarse and arrayed irregularly like a grid. All patients underwent the diagnostic biopsy. Under microscopic observation, the bone structures were arranged disorderly, the trabeculae were thickened and enriched with osteoclasts and osteoblasts, irregular blue cement line were also seen in thickened trabeculae, the bone marrow were replaced by the fibrovascular connective tissue. All patients were given calcitonin and diphosphonates as medical treament. Results In the follow up period of an average of 16 months(range 3-26 months), one patients had pain relief at lesioned hip but functional limitation remained, the others did not have any sign of malignant progression. The serum alkaline decreased dramatically and the involved bone did not present with deteriorated change. They were working as usual. Conclusion Osteitis deformans is a disorder of bone architecture resulting from disturbance in the rate of bone turnover; typical radiographic and pathologic feature is the important points for definite diagnosis of osteitis deformans.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
2002年第2期100-102,共3页
Chinese Journal of Orthopaedics
