摘要
目的 探讨精神分裂症患者认知功能缺损与氧化应激的关系。方法 对 39例精神分裂症患者 (患者组 ) ,36名健康对照者 (对照组 )进行神经心理测验和氧化应激指标的检测。结果(1)在神经心理测验中 ,患者组与对照组在总测验数、总错误数、持续错误数、语言流畅、领悟、相似和联想学习的差异有非常显著性 (P <0 0 1) ,数字广度的差异有显著性 (P <0 0 5 ) ;(2 )患者组的一氧化氮 (NO)浓度与WCST的总错误数呈显著性正相关 ,与相似测验呈显著性负相关 ,超氧化物歧化酶(SOD)活性与相似性测验、数字广度测验呈显著性负相关 (r分别为 0 4 0 9,- 0 4 0 4,- 0 4 32 ,- 0 4 2 0 ,P <0 0 5 )。结论 (1)精神分裂症认知功能缺损的生物学基础可能与氧化应激有关 ;(2 )SOD和NO可能是与认知功能密切相关的氧化应激指标。
Objective To explore the relationship between cognitive deficits and oxidative stress in schizophrenia. Method Thirty-eight patients with schizophrenia and 36 controls were entered in the study. Cognitive functions were measured with neuropsychological tests such as the Wisconsin Card Sorting Test (WCST), semantic fluency, digit span test and so on. Oxidative stress indexes including the activity of superoxide dismutase (SOD) and serum nitric oxide (NO) were assayed. Results (1)The total number, total error number and persistent error number of WCST in patients was higher than that in controls (91.5±25.5 vs. 71.0±23.8; 68.1± 28.2 vs. 46.0±23.8;35.2±19.4 vs. 21.0±9.3,P<0.01). As to the semantic fluency, comprehension, similarity, association learning and digit span test, the patients got significantly lower scores than controls (37.1± 10.3 vs. 53.5±14.0; 9.3±3.7 vs. 12.7±2.1;10.5±2.8 vs. 12.3±1.9;19.0±7.0 vs. 23.7±5.5;12.0±2.3 vs.13.8±3.1,P<0.01 or 0.05). (2) The serum NO level was positively correlated with WCST total error number (r=0.409, P<0.05) and negatively with similarity test score (r= -0.404 , P<0.05) . The the activity of SOD was negatively correlated with similarity test score and digit span test score (r=-0.432 , P<0.05;r= -0.420 , P<0.05). Conclusion (1)The cognitive deficits in schizophrenia may be related with oxidative stress. (2) The activity SOD and serum NO can be as the oxidative stress indexes which are closely related to cognitive deficits in schizophrenia.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2002年第1期7-10,共4页
Chinese Journal of Psychiatry
基金
国家自然科学基金资助项目 ( 39970 2 72 )
