摘要
目的 :制备阿苯达唑聚氰基丙烯酸酯口服纳米球 (ABZ-PBCA-NP) ,并考察其体外累积溶出速率。方法 :采用乳化聚合二步法制备阿苯达唑口服纳米球 ,以包封率为考察指标 ,应用 L9(3 4 )正交试验设计优化处方。同时 ,以原料药混悬液对照 ,进行体外动态释药试验。结果 :当空白纳米球 p H为 5 .0 ,与阿苯达唑液的体积比 1.2∶ 1,氰基丙烯酸正丁酯浓度为 1%时 ,制备口服纳米球的包封率最高 ,即 (60 .0 3± 5 .5 0 ) %。在 p H=5 .0的磷酸缓冲溶液中 ,阿苯达唑口服纳米球释药符合 Higuchi方程 ,阿苯达唑混悬液释药符合威布尔分布函数。结论
OBJECTIVE:To perpared the albendazole nanoparticles and test cumulated dissolutions of albendazole from two different drugs.METHOD:We used “two step emulsion polymerization method” to prepare albendazole nanoparticles and conducted the L 9(3 4) orthogonal design to seek optimum method with the entrapment effciency as the standard. At the same time, with pH=5.0 phosphatic buffer solution as the medium, the cumulation dissolution of albendazole from two type drugs were determined and the release rules were research with three functions: single Exponential, Weibull and the Higuchi.RESULTS:the optimum description is in which the blank nanoparticles pH=5.0 were dripped slowly at the basis of 1.2:1 (V/V) into the albendazole raw suspension in which contained 1% α butylcyanocrylate. Then, according to the better description we prepared the albendazole nanoparticles and (60.03±5.50)% entrapment effciency was obtain. The dissolution test compared with that of albendazole raw materials had indicated the released test of albendazole nanoparticles conformed to Higuchi function, and that of albendazole raw materials were in keeping with weibull function.CONCLUSION:‘the two step optimum method’ is efficient to prepare the albendazole napoparticles. The higher drug entrapment efferency was obtained and the drug relaxedly released from the nanoparticles.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2002年第2期114-117,共4页
Chinese Journal of Modern Applied Pharmacy
