摘要
回顾性总结穿透性角膜移植术 ( penetratingkeratoplasty ,PKP)后急性内皮型免疫排斥反应发生的时间规律。方法 :对我院 6年来实施的PKP病例进行回顾性分析 ,对发生过急性内皮型免疫排斥反应的 2 5 6例病例 ,详细总结免疫排斥反应发生的时间、次数 ,以及发生的原因、预后等。结果 :76 5 3 % ( 196 /2 5 6 )的首次排斥反应发生在术后 1年内 ,19 14 % ( 4 9/2 5 6 )发生在术后 2年内 ,只有 11例发生在 2年以后。二次排斥距首次排斥的时间 1～ 16 5个月 ,平均 4 8个月。真菌性角膜炎病例的排斥发生时间相对较提前 ,73 8% ( 6 2 /84)集中在术后 8个月内。其中全角膜移植者多发生在术后 2周内。HSK病例在术后 6～ 9个月份和 13～ 17个月各有一个高峰。细菌性角膜溃疡病例发生的较分散 ,但是主要集中在 3～ 11个月之间。结论 :掌握这些规律对临床治疗和研究具有重要指导意义。
Objective:To review the characteristics at occurrence time of corneal endothelial rejection after penetrating keratoplasty (PKP). Methods:Retrospective analysis of 256 cases of PKP which suffered endothelial rejection episodes in our hospital during 1995～2000.The time point of rejection occurrence,the risk factors and the prognosis were recorded. Results:In 76 53% (196/256) of the patients,the first rejection episodes occurred within 1 year after PKP.19 14% (49/256) occurred in 2 years after surgery.There were only 11 cases occurred after 2 years of PKP.The second rejection occurred at 1～16 5 months after the first rejection,the average interval was 4 8 months.The rejection occurred much earlier in the cases of fungal keratitis.73 8% (62/84) occurred within 8 months after surgery.The rejection in most full corneal transplantation cases occurred within 2 weeks after surgery.In HSK group,the rejection rate was higher at 6～9 months and 13～17 months after surgery.The occurrence time was dispersive but had a peak at 3～11 months after surgery in bacterial keratitis. Conclusions:To understand these characteristics is helpful for clinical management and basic study.
出处
《中国实用眼科杂志》
CSCD
北大核心
2002年第3期175-177,共3页
Chinese Journal of Practical Ophthalmology
基金
山东省眼科研究所医药卫生九五攻关课题资助 (资助号 :970 91 6)
关键词
角膜移植
穿透
免疫排斥
时间
Penetrating keratoplasty,Endothelial rejection time
